BLOOD CLOT MODELLING

Sep 23, 2014

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Marek Čapek, Charles University in Prague, Faculty of Mathematics and Physics, Prague, Czech Republic The mathematical modelling of the blood coagulation process presents a challenge. In the poster we present a novel approach to such a kind of modelling. We will focus on the modelling of the blood clot emerging on the place of the vessel wall injury. The clot is the result of the series of the chemical reactions. We will restrict our model to a subset of the chemical reactions because of simplicity. The blood clot is treated as a biofilm using phase field method. The emerging equations are solved via finite element method.

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MOdelling REvisited + MOdel REduction Modeling, analysis and computing in nonlinear PDEs. September 21-26, 2014, Chateau Liblice, Czech Republic. Recently developed implicit constitutive theory allows one to describe nonlinear response of complex materials in complicated processes and to model phenomena in both fluid and solid mechanics that have hitherto remained unexplained. The theory also provides a thermodynamically consistent framework for technologically important but so far only ad hoc engineering models without sound footing. The overall goal of the project is to develop accurate, efficient and robust numerical methods that allow one to perform large-scale simulations for the models arising from the new theoretical framework. A natural part of the goal is rigorous mathematical analysis of the models. The nonstandard structure of constitutive relations arising from the new framework requires the reconsideration of many existing approaches in the mathematical theory of partial differential equations and the development of new ones. In particular, basic notions such as the concept of the solution and its well-posedness need to be reconsidered. Further, the complexity of the constitutive relations calls for rigorous investigation on model reduction - the identification of simplified models that capture the chosen (practically relevant) information about the behaviour of the system and disregard irrelevant information. Reliable numerical simulations require the derivation of sharp a posteriori error estimates to control all possible sources of errors, including rarely studied but important algebraic errors. We believe that in solving difficult problems in mathematical modelling the individual aspects discussed above - physics, mathematical analysis and numerical analysis - are so closely interrelated that no breakthrough can be achieved without emphasising the holistic approach as the main principle. Our vision is to follow this principle: the entire process of modelling of complex materials will be revisited in an innovative manner.

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