Over the past 30 years, the U.S. and Central Europe have worked together to re-embed the region into the Western-driven liberal democratic order that relies on the rule of law, multilateralism, and cooperative institutions. The world has been changing rapidly, however, and today we live in a very different place than 30 years ago. The global competition is intensifying, with great powers repeatedly finding themselves on the brink of trade wars. Technological progress has been changing the way we live and work at a pace that exceeds the ability of institutions to reap its benefits and neutralize potential challenges, including the abuse of technologies by illiberal powers. Growing in confidence, China is insidiously imposing its economic conditions and domination that spills over to the political realm. Europe has been focusing on Brexit, neglecting a wide array of other concerns. The faith in multilateralism is shaken. In this environment, navigating the disrupted world alone is a strategy that is unlikely to deliver success. The U.S. and Europe, with Central Europe being an integral part of it, need each other to withstand the global competition in every domain: economy, technology, values, and way of life. How can we revive the transatlantic partnership to sustain the rule-based order and prosper in an increasingly competitive world? What is the place of Central Europe in the US grand strategy? How can we join forces to sustain, or even regain, technological leadership?