Rita Kočárová, MSc. - As humans, we have had interactions with psychoactive substances in a variety of contexts throughout our history. Those often powerful interactions will be explored from the perspectives of epistemiology, safety, morality, their nature and effect. Main underlying driving forces of this relationship will be discussed. There are many adverse effects and risks related to the use of psychedelics often not presented appropriately in the society. Psychoactive substances can be powerful tools in facilitating sanity or illness, joy or fear, war or peace; depending on what, who and how is using them. There is no sensible reason why psychedelics should not be legal, or, to use a more specific term, rationally regulated. We have to move towards creating an intelligent society which treats psychoactive substances responsibly and safely. To do so, besides rigorous clinical research, also review of the history, an acceptance of the rich variety of their use, proper evaluation of their real risks and safety, their representation in society and relationship they have with us as a humans are necessary.