N,N-dimethyltryptamine (DMT) is a naturally occurring classical hallucinogen with significant affinity at 17 known receptor sites. It has also been classified as an endogenous hallucinogen. The vast majority of research on DMT has been targeting its psychotropic properties and serotonergic activity with less focus on its effects beyond the nervous system and at other receptor molecules. The recent discovery that DMT is an endogenous ligand of the sigma-1 receptor may shed light on yet undiscover…