The Cancer Registry of Norway (CRN) collects, curates, and manages data related to cancer patients in Norway, supported by an interactive, human-in-the-loop, socio-technical decision support software system. Automated software testing of this software system is inevitable\; however, currently, it is limited in CRN’s practice. To this end, we present an industrial case study to evaluate an AI-based system-level testing tool, i.e., EvoMaster, in terms of its effectiveness in testing CRN’s software system. In particular, we focus on GURI, CRN’s medical rule engine, which is a key component at the CRN. We test GURI with EvoMaster’s black-box and white-box tools and study their test effectiveness regarding code coverage, errors found, and domain-specific rule coverage. The results show that all EvoMaster tools achieve a similar code coverage\; i.e., around 19% line, 13% branch, and 20% method\; and find a similar number of errors\; i.e., 1 in GURI’s code. Concerning domain-specific coverage, EvoMaster’s black-box tool is the most effective in generating tests that lead to applied rules\; i.e., 100% of the aggregation rules and between 12.86% and 25.81% of the validation rules\; and to diverse rule execution results\; i.e., 86.84% to 89.95% of the aggregation rules and 0.93% to 1.72% of the validation rules pass, and 1.70% to 3.12% of the aggregation rules and 1.58% to 3.74% of the validation rules fail. We further observe that the results are consistent across 10 versions of the rules. Based on these results, we recommend using EvoMaster’s black-box tool to test GURI since it provides good results and advances the current state of practice at the CRN. Nonetheless, EvoMaster needs to be extended to employ domain-specific optimization objectives to improve test effectiveness further. Finally, we conclude with lessons learned and potential research directions, which we believe are applicable in a general context.