The management of therapeutic use of the plants in traditional Amazonian medicine requires strict rules and precautions. The respect of these rules during and after the ritual, (be purges, diets, and ayahuasca), conditions the result of the process. These rules are of food and sexual order. Their transgression leads to disturbances/perturbations at the physical, psychological, energetic / spiritual level, from the lightest to the most several. In the Amazonian healer tradition, these perturbations are called: “cruzaderas” We will analyse this topic, starting from the acclamation of ritual’s importance, reasons behind the rules, using clinical examples.