Questions in biology and medicine pose big challenges to existing ML methods. The impact of creating ML methods to address these questions may positively impact all of us as patients, as scientists, and as human beings. In this tutorial, we will cover some of the major areas of current biomedical research, including genetics, the microbiome, clinical data, imaging, and drug design. We will focus on progress-to-date at the intersection of biology, health, and ML. We will also discuss challenges and open questions. We aim to leave you with thoughts on how to perform meaningful work in this area. It is assumed that participants have a good grasp of ML. Understanding of biology beyond high school level is not required.